Research shows physical activity reduces the risk of a variety of #cancer types,

mayo physical activity

4 hours ago

Research not only shows that physical activity reduces the risk of a variety of types, it also suggests that people with a cancer diagnosis should be active throughout all stages of survivorship. Read more on .

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Is it possible to catch up on lost sleep over the weekend?@ClevelandClinic

6 hours ago

Is it possible to catch up on lost sleep over the weekend? A sleep medicine expert’s answer:

Q: Is It OK to catch up on lost sleep over the weekend?

A: In the past, sleep experts believed it was impossible to catch up on the sleep you lose — that once you’ve lost it, it’s gone.

But a recent long-term study found that folks who slept four, five or six hours during the week, then caught up on weekends, lived longer than those who remained sleep-deprived all week long.

So you can catch up to some degree on weekends. However, sometimes people who catch up on sleep on the weekend will oversleep.

And it turns out that oversleeping has some of the same consequences as undersleeping:

  • Oversleeping is associated with depression, which is linked to a host of other health problems.
  • Research suggests that oversleeping can make people groggy and cognitively impaired.
  • Studies suggest oversleeping increases risks of cardiovascular disease, diabetes and obesity as much as undersleeping, because toxins and inflammatory markers build up.

So it’s really best to aim for a stable sleep time, bedtime and wake time every day of the week. This will help you get the regular sleep needed to restore your brain and every cell in your body.

—Sleep medicine specialist Nancy Foldvary-Schaefer, DO, MS

“Piglet?” said Pooh. “Yes Pooh?” said Piglet. “Do you ever have days when everything feels… Not Very Okay At All?

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“Piglet?” said Pooh. “Yes Pooh?” said Piglet. “Do you ever have days when everything feels… Not Very Okay At All? And sometimes you don’t even know why you feel Not Very Okay At All, you just know that you do.” Piglet nodded his head sagely. “Oh yes,”

Ethanol is one of the few nutrients that is profoundly toxic.

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Abstract

Ethanol is one of the few nutrients that is profoundly toxic. Alcohol causes both whole-body and tissue-specific changes in protein metabolism. Chronic ethanol missuse increases nitrogen excretion with concomitant loss of lean tissue mass. Even acute doses of alcohol elicit increased nitrogen excretion. The loss of skeletal muscle protein (i.e., chronic alcoholic myopathy) is one of several adverse reactions to alcohol and occurs in up to two-thirds of all ethanol misusers. There are a variety of other diseases and tissue abnormalities that are entirely due to ethanol-induced changes in the amounts of individual proteins or groups of tissue proteins; for example, increased hepatic collagen in cirrhosis, reduction in myosin in cardiomyopathy, and loss of skeletal collagen in osteoporosis. Ethanol induces changes in protein metabolism in probably all organ or tissue systems. Clinical studies in alcoholic patients without overt liver disease show reduced rates of skeletal muscle protein synthesis though whole-body protein turnover does not appear to be significantly affected. Protein turnover studies in alcohol misusers are, however, subject to artifactual misinterpretations due to non-abstinence, dual substance misuse (e.g., cocaine or tobacco), specific nutritional deficiencies, or the presence of overt organ dysfunction. As a consequence, the most reliable data examining the effects of alcohol on protein metabolism is derived from animal studies, where nutritional elements of the dosing regimen can be strictly controlled. These studies indicate that, both chronically and acutely, alcohol causes reductions in skeletal muscle protein synthesis, as well as of skin, bone, and the small intestine. Chronically, animal studies also show increased urinary nitrogen excretion and loss of skeletal muscle protein. With respect to skeletal muscle, the reductions in protein synthesis do not appear to be due to the generation of reactive oxygen species, are not prevented with nitric oxide synthase inhibitors, and may be indirectly mediated by the reactive metabolite acetaldehyde. Changes in skeletal muscle protein metabolism have profound implications for whole body physiology, while protein turnover changes in organs such as the heart (exemplified by complex alterations in protein profiles) have important implications for cardiovascular function and morbidity.

https://www.ncbi.nlm.nih.gov/pubmed/10422097